The peaks over threshold (POT) model for catastrophe (CAT) reinsurance pricing has been widely used, but has mainly focused on univariate CAT reinsurance pricing.We provide further justification and support for the model by considering the addition of more than one type of CAT risk in the context of extreme value theory.We further extend the applic
Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies.Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks.Zebrafish harbor homologs
Background: The population of older adults is growing in sub-Saharan Africa.Ageing exponentially increases fragility fracture risk.Of all global regions, Africa is projected to observe the greatest increase in fragility fractures.Fractures cause pain, disability and sometimes death, and management is expensive, often requiring complex healthcare de
Abstract Long noncoding RNAs (lncRNAs) are key regulators during gastric cancer (GC) development and may be viable treatment targets.In the present study, we showed that the expression of the long intergenic noncoding RNA 01016 (LINC01016) is significantly higher in GC tissues with lymph node metastasis (LNM) than those without LNM.LINC01016 overex